Zerenia Clinic UK

Medical Cannabis

Cannabis has been used for millennia and there is a substantial body of anecdotal evidence related to its psychoactive and therapeutic effects.

Cannabinoids are active molecules unique to the cannabis plant, and remain the only molecules clinically approved for the pharmacological modulation of the endocannabinoid system.

Distinction between "Indica" and "Sativa" is related to botanical features of the cannabis subspecies rather than to differences in pharmacological or psychoactive profiles.

Although the cannabis plant may contain hundreds of molecules, its pharmacological effect is determined by the relative abundance of THC and CBD, which defines its chemotype.

The Endocannibinoid System

The Endocannabinoid System is a lipid signaling system that modulates many physiological processes in the whole organism favoring homeostasis. Its key components include:

• Type-1 and type-2 cannabinoid (CB1 and CB2) receptors:

Cannabinoid recptors are G protein-coupled receptors that mediate several intracellular processes such as the closure of calcium channels and the inhibition of adenylate cyclase. CB1 receptors are predominantly expressed in the nervous and musculoskeletal system, the gastrointestinal tract and adipose tissue. CB2 is primarily expressed in cells of the immune system, including the glia.

• Endocannabinoids:

The endogenous ligands of CB1 and CB2 are lipid messengers derived from arachidonic acid called “endocannabinoids”, namely N-arachidonoyl ethanolamide (“anandamide”) and 2-arachidonoylglycerol (2-AG). Δ9-tetrahidrocannabinol (THC), the main active component of cannabis, mimics the action of anandamide and 2-AG by acting as a partial agonist of both CB1 and CB2. Central activation of CB1 receptors by THC is responsible for the classical psychoactivity associated to cannabis consumption.
Graphic with explanations about the Endocannabinoid System

Δ9-tetrahydrocannabinol

THC exerts its pharmacological actions by activating cannabinoid receptors CB1 and CB2 and is responsible for most of the therapeutic effects of cannabis, which may help with symptomatic alleviation in several conditions such as chronic pain, nausea and vomiting induced by chemotherapy, multiple sclerosis, and other neurological disorders. In high doses, THC can also elicit adverse effects such as anxiety, euphoria, paranoia, etc.

Cannabidiol

CBD does not activate CB1 or CB2 receptors and, therefore, does not cause euphoria and is generally well tolerated. However, it may modulate the therapeutical profile of THC, improving its tolerability and safety. Inhalation of CBD may help with the symptomatic alleviation of different clinical conditions such as chronic headache and migraine, chronic pelvic pain, inflammatory bowel diseases, stress and anxiety disorders, and substance use disorder (as a harm reduction
strategy).

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Our friendly patient care coordinators will contact you to answer any questions you may have and to help you on your medical cannabis journey.
  • Book appointment and follow ups
  • Carry out quick eligibility assessments
  • Provide more information on medical cannabis and the conditions we treat

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